Naming an Influenza Virus

For an updated version of this article – please see Naming the 2015-2016 Influenza Viruses

Fall is in the air, temperatures are getting colder, and flu season is about to begin. Soon, we will be seeing news reports about H1N1 and H3N1 swine flu outbreaks. But what exactly do these names mean?

First, it is important to recognize that there are several different forms of influenza. Influenza A and Influenza B are the two most prevalent forms that infect humans. Influenza viruses are typically named according to their type (A or B), host, geographical origin, year of isolation -etc. For example, this year’s flu vaccine contains protection against the following strains

A/California/7/2009 (H1N1)-like virus

A/Victoria/361/2011 (H3N2)-like virus

B/Wisconsin/1/2010-like virus

Notice how the Influenza A viruses also contain a separate designation, in this case either H1N1 or H3N2. Only Influenza A viruses contain this additional label, and increasingly, this is how they are referred to in the media. So what exactly does a name like H3N2 mean?

The H and N in the name have nothing to do with the severity of the flu symptoms. Rather, it is based on the structure of a virus. So lets take a quick moment to review the general structure of a virus:

virus

from Biology 11e by Mader/Windelspecht – used by permission

Remember that the purpose of a virus is to hijack a host cell and make lots of copies of itself (see our Viral Life Cycle animation for more information). The genome of a virus may be either DNA or RNA (it is RNA in influenza) and it contains the instructions for making new viruses. The protein capsid encloses the genome. In influenza viruses, the capsid is surrounded by a membrane-like structure called an envelope. The spikes in this diagram are glycoproteins that assist the virus in identifying and entering its host cell.

Now, lets focus on the H and N aspects of an influenza virus. Notice how in the diagram of an influence virus below that there are several different forms of glycoprotein spikes  on the surface of the virus.

virus

image courtesy of the CDC

For influenza A viruses, there are two important forms of these spikes – H spikes and N spikes.  H spikes are associated with hemagglutinin, a type of glycoprotein that assists the virus in identifying the receptors on the host cell.  The N spikes are an enzyme called neuraminidase. N spikes help break down the mucous material surrounding host cells in the respiratory tract and initiate penetration of the virus into the host cell.

These spikes are not the same in all influenza A viruses. There are over 17 different known forms of H spikes, and 10 different variations in N spikes. These variations are what gives the influenza A viruses their distinct name. In humans, H1N1 and H3N2 are the two forms of influenza A the contribute to the normal seasonal flu outbreak. So, for example, the H1N1 virus has hemagglutinin form 1 and neuraminidase form 1.

Here are some additional examples of influenza A names in other animals:

viruses

Notice that H5N1 (avian flu) has a number of hosts, while others (H13N9 – whales) are fairly host specific. Interestingly, birds are hosts for all variants of influenza A. These types of relationships help scientists identify not only reservoirs for the virus, but from where future outbreaks may originate.

Additional Resources:

Images:

This post was updated in April 15, 2015 with new image information.

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