Variations in Meiosis: The Parthenogenetic Lizards

For most students in introductory biology, the diagram below is a familiar one. it represents the process of genetic recombination (crossing-over) during prophase I of meiosis. Effectively, this is the first step in the shuffling of the genome in meiosis – and it represents a very important first step in the generation of variation. And, as most students can tell you, crossing-over occurs between non-sister chromatids of homologous chromosomes. Why?  Because while the homologous chromosomes are similar (one comes from each parent), the alleles of the genes that they contain may be slightly different – thus the mixing of the two can result in new genetic combinations.

Meiosis

Meiosis – Essentials of Biology 3e (McGraw-Hill Education) – used by permission

Usually, I get a question from the group as to whether crossing-over can occur between the sister chromatids themselves. After some discussion, we usually come to the conclusion that this would defeat the purpose of crossing-over, since the sister chromatids are genetically identical. But then the picture becomes a little more cloudy when they are told that crossing-over does occur between the sister-chromatids.  So therefore, if one of the purposes of meiosis is the introduction of variation, then why conduct crossing-over between what are effectively cloned pieces of DNA?
A paper I came across in Nature from last year explains a potential reason why – if you are  a parthenogenetic species (reproduction without males), you lack the ability to obtain genetic variation from your mate. Over time, this effectively limits the amount of genetic variation in the species – never a good thing from an evolutionary perspective. However, researchers from at team at the Howard Hughes Medical Institute discovered that in a parthenogenetic species of lizards (whiptail lizards; genus Aspidoscelis) that crossing-over does occur between the sister chromatids. Furthermore, this crossing-over is responsible for the maintenance of genetic heterozygosity(containing 2 different alleles) in the species.
DesertGrasslandWhiptailLizard_AspidoscelisUniparens56
How does this occur?To make this possible, the species doubles the number of chromosomes prior to meiosis – effectively making an additional copy of the genome and forming a pair of homologous chromosomes from a single parent. This doubling allows the reduction division in meiosis to produce diploid (2n) gametes, a requirement for many species that undergo parthenogenesis. Then, the species allows for crossing-over to occur between the sister chromatids themselves. Since there are always slight differences in the sister-chromatids (they are never truly identical), small amounts of variation are maintained in the genome, and this is passed onto the next generation.
As the author’s note, a better understanding of this process may lead to insight on the processes of the evolution of sexual reproduction. It should be noted that this paper is well-written and could be used in an introductory genetics or cell biology course. The methods are well-presented and the graphics and images would be very useful for students.

Additional Links:

  • Lutes A.A., Neaves W.B., Baumann D.P., Wiegraebe W. & Baumann P. (2010). Sister chromosome pairing maintains heterozygosity in parthenogenetic lizards, Nature, 464 (7286) 283-286. DOI:

 Photo Credits

whiptail lizards: By Ltshears (Own work) [CC BY-SA 3.0 (http://creativecommons.org/licenses/by-sa/3.0)], via Wikimedia Commons

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